Anti-TDP43 antibody [2E2-D3] ab57105 from Abcam

Product Specs
ItemAnti-TDP43 antibody [2E2-D3]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab57105
Antibody TypePrimary
ApplicationsFlow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Sandwich ELISA, Western blot
ClonalityMonoclonal
HostMouse, Nude mouse
IsotypeIgG1
Quantity100 UG
Conjugate/TagUnconjugated
Concentration0.32 mg/ml
Clone2E2-D3
Research AreaNeuroscience
Gene NameTARDBP
ReactivityHuman, Recombinant fragment
TargetTDP43

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDPNatureAugust 2, 2023Diana Arseni, Renren Chen, Alexey G. Murzin, Sew Y. Peak-Chew, Holly J. Garringer, Kathy L. Newell, Fuyuki Kametani, Andrew C. Robinson, Ruben Vidal, Bernardino Ghetti, et al.saline (PBS) and then incubated overnight with primary antibodies against the TDP-43 N terminus (Abcam ab57105, 1:10,000, or Proteintech 10782-2-AP, 1:2,000) and pS409/410 TDP-43 (CosmoBio CAC-TIP-PTD-M01, 1:1,000)

(2) Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteasesMolecular neurodegenerationMay 2, 2023Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW.#F3040, 1:1000), 3) mouse anti-α-synuclein (Cell Signaling #2647S, 1:1000), 4) mouse anti-TDP-43 (Abcam #ab57105, 1:1000), 5) mouse anti-Tau (Santa Cruz #sc-1995, 1:1000), 6) anti-rabbit anti-Lamp1 antibody (Cell Signaling

(3) CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1The Journal of cell biologyJanuary 3, 2022Deng X, Sun X, Yue W, Duan Y, Hu R, Zhang K, Ni J, Cui J, Wang Q, Chen Y, et al.(Cell Signaling Technology; 3724), rabbit anti–TDP-43 (Proteintech; 10782–2-AP), mouse anti–TDP-43 (Abcam; ab57105), mouse anti-P62/SQSTM1 (Proteintech; 66184–1-Ig), rabbit anti-LC3B (Abcam; ab48394), rabbit anti-ATG8A/GABARAP

(4) TDP-43-specific Autoantibody Decline in Patients With Amyotrophic Lateral SclerosisNeurology(R) neuroimmunology & neuroinflammationMarch 1, 2021Nielsen AK, Folke J, Owczarek S, Svenstrup K, Winge K, Pakkenberg B, Aznar S, Brudek T.calibrator control in a 2-fold serial dilution with primary monoclonal mouse anti–TDP-43 antibody (#ab57105; Abcam) and detected with a secondary biotinylated anti-mouse IgG antibody (#BA-9200; Vector, Burlingame,

(5) Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathyPLOS GeneticsDecember 13, 2019Nicole F. Liachko, Aleen D. Saxton, Pamela J. McMillan, Timothy J. Strovas, C. Dirk Keene, Thomas D. Bird, Brian C. Kraemer4–15% gradient Tris: HCL gels (Biorad). Total human TDP-43 was detected with mouse monoclonal antibody ab57105 (Abcam) and phosphorylated TDP-43 was detected with mouse monoclonal antibody TIP-PTD-M01 (CosmoBio).

(6) Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohortActa neuropathologica communicationsJune 7, 2019Latimer CS, Burke BT, Liachko NF, Currey HN, Kilgore MD, Gibbons LE, Henriksen J, Darvas M, Domoto-Reilly K, Jayadev S, et al.(Bio-Rad). Membranes were blocked in 5% milk; total TDP-43 was detected with mouse monoclonal antibody ab57105 (Abcam) and phosphorylated TDP-43 (pS409/410) was detected with mouse monoclonal antibody TIP-PTD-M01

(7) Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegenerationMolecular NeurodegenerationDecember 1, 2018Laura M. Taylor, Pamela J. McMillan, Nicole F. Liachko, Timothy J. Strovas, Bernardino Ghetti, Thomas D. Bird, C. Dirk Keene, Brian C. KraemerImmun-blot PVDF membrane) at 100 V for 32 m. Human TDP-43 was detected with the commercially available monoclonal antibody ab57105 (Abcam, 1:2500) directed at human TDP-43 amino acids 1-261. TDP-43 phosphorylated at S409/S410 was detected

(8) Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid InteractomeScientific ReportsDecember 1, 2017Jayanth S. Chandran, Paul S. Sharp, Evangelia Karyka, João Miguel da Conceição Aves-Cruzeiro, Ian Coldicott, Lydia Castelli, Guillaume Hautbergue, Mark O. Collins, Mimoun Azzouz

(9) The phosphatase calcineurin regulates pathological TDP-43 phosphorylationActa NeuropathologicaOctober 1, 2016Nicole F. Liachko et al.recommended by the manufacturer (Bio-Rad). On immunoblots, human TDP-43 was detected by anti-TDP-43 (Abcam ab57105). TDP-43 phosphorylated at S409/S410 was detected by a monoclonal antibody anti-phospho TDP-43 (pS409/410)

(10) Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein ClearanceJournal of NeuroscienceOctober 21, 2015Angela M Jablonski et al.following antibodies were used in this study: hR23A (Abcam ab55725), hR23B (Abcam ab88053), TDP-43 (Abcam ab57105 for immunoblotting), myc (Cell Signaling Technology 2276), hSOD1 (Abcam ab52950), V5 (EMD Millipore

(11) The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 LevelsJournal of NeuroscienceJune 24, 2015Dominique A Salazar et al.(Sigma-Aldrich, no. F3165, dilution 1:1000) to detect FLAG-tagged granulin; antihuman TDP-43 (Abcam, no. ab57105, dilution 1:500); anti-phosphoTDP-43 (Cosmobio, 11-9, dilution 1:1000), anti-actin (Millipore, no. MAB1501R,

(12) The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43PLoS geneticsDecember 1, 2014Liachko NF, McMillan PJ, Strovas TJ, Loomis E, Greenup L, Murrell JR, Ghetti B, Raskind MA, Montine TJ, Bird TD, et al.Phosphorylate TDP-43 protocol in the TriFECTa Dicer-Substrate RNAi manual (Integrated DNA Technologies). ab57105 (Abcam) directed against human TDP-43 amino acids 1– 261. TDP-43 phosphorylated at S409/S410 was detected

(13) Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patientsNature communicationsSeptember 12, 2014Fang YS, Tsai KJ, Chang YJ, Kao P, Woods R, Kuo PH, Wu CC, Liao JY, Chou SC, Lin V, et al.in PBS solution at RT for 1 h. After blocking, the grids were labelled by N1-260 antibody (1:5,000, ab57105, Abcam) in 0.1% BSA containing PBS solution at RT for 1 h and washed by high-salt Tween buffer (50 mM

(14) Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43The Journal of biological chemistryApril 11, 2014Stribl C, Samara A, Trümbach D, Peis R, Neumann M, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Rathkolb B, Wolf E, et al.

(15) HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expressionPloS oneJanuary 1, 2014Julia Nehls, Herwig Koppensteiner, Ruth Brack-Werner, Thomas Floss, Michael Schindler

(16) Identification of LIN28B-bound mRNAs reveals features of target recognition and regulationRNA BiologyJuly 1, 2013Robin Graf, Mathias Munschauer, Guido Mastrobuoni, Florian Mayr, Udo Heinemann, Stefan Kempa, Nikolaus Rajewsky, Markus LandthalerMethods Antibodies anti-HA.11 (COVANCE, 16B12), anti-FLAG (SIGMA, F1804), anti-LIN28B (Cell Signaling, 4196) anti-TARDP (Abcam, ab57105), anti-HNRNPK (Abcam, ab52600), anti-RPL7 (Abcam, ab72550), anti-UPF1 (Bethyl, A300-036A), anti-VCL

(17) CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegenerationAnnals of neurologyJuly 1, 2013Liachko NF, McMillan PJ, Guthrie CR, Bird TD, Leverenz JB, Kraemer BC.(Bio-Rad). On immunoblots, human TDP-43 was detected with a commercially available monoclonal antibody ab57105 (Abcam) directed against human TDP-43 amino acids 1-261. TDP-43 phosphorylated at S409/S410 was detected

(18) Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 ProteinopathyJournal of NeuroscienceDecember 1, 2010Nicole F. Liachko, Chris R. Guthrie, Brian C. Kraemer(Bio-Rad). On immunoblots, human TDP-43 was detected with a commercially available monoclonal antibody ab57105 (Abcam) directed against human TDP-43 amino acids 1–261. TDP-43 phosphorylated at S409/S410 was detected

(19) CELF proteins regulate CFTR pre-mRNA splicing: essential role of the divergent domain of ETR-3Nucleic acids researchNovember 1, 2010Gwendal Dujardin, Emanuele Buratti, Nicolas Charlet-Berguerand, Mafalda Martins de Araujo, Annick Mbopda, Catherine Le Jossic-Corcos, Franco Pagani, Claude Ferec, Laurent Corcos

(20) Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene trapsNucleic acids researchMay 1, 2010Schebelle L, Wolf C, Stribl C, Javaheri T, Schnütgen F, Ettinger A, Ivics Z, Hansen J, Ruiz P, von Melchner H, et al.polyclonal Antibody (dilution: 1:1500) and TARDBP monoclonal antibody: anti-human TARDBP antibody (ab57105; ABCAM; 1.25 µg/ml). For signal detection, ECL Detection Reagents I + II (GE Healthcare UK Limited)

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Anti-TDP43 antibody [2E2-D3] from Abcam

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Anti-TDP43 antibody [2E2-D3] from Abcam

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